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Abortion pills refer to a two-medication protocol: mifepristone and misoprostol. This combination is FDA-approved and widely recognized as a safe and effective method for ending a pregnancy up to 10-12 weeks. Mifepristone works by blocking the hormone progesterone needed for a pregnancy to continue, while misoprostol causes the uterus to empty. Together, they have a success rate of over 95%, making medication abortion one of the most trusted reproductive healthcare options available today.
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1. Mifepristone (RU-486): Mifepristone is the most widely used abortion pill, FDA-approved for use up to 10 weeks (70 days) of pregnancy. It works by blocking progesterone, the hormone needed to sustain a pregnancy, effectively stopping the pregnancy from progressing. It is almost always used as the first step in a two-drug protocol and is considered the most reliable first-line medication abortion option available today.
2. Misoprostol (Used Alone): When used on its own, misoprostol is effective for pregnancies up to 10 weeks (70 days), though it is most commonly recommended for use up to 7 weeks for the highest success rate. It works by causing the uterus to contract and expel the pregnancy. While it is less effective than the combination protocol, it remains a widely used option in regions where mifepristone is not accessible.
3. Mifepristone + Misoprostol Combination: The gold standard in medication abortion, this two-drug combination is FDA-approved and recommended by the WHO for pregnancies up to 10-12 weeks. With a success rate of over 95%, it is the most effective non-surgical abortion method available. Mifepristone is taken first, followed by misoprostol 24 to 48 hours later to complete the process.
4. Methotrexate + Misoprostol: This older protocol is effective for pregnancies up to 7 weeks (49 days). Methotrexate is typically used when mifepristone is not available, working by stopping the growth of pregnancy cells. Misoprostol is then taken 3 to 7 days later to complete the abortion. While it has a slightly lower success rate compared to the mifepristone combination, it remains a viable and medically recognized option for early pregnancies.
5. Emergency Contraception (Morning-After Pills): Emergency contraception such as Plan B and ella are effective when taken within 72 to 120 hours after unprotected sex, before a pregnancy is established. Plan B is most effective within the first 72 hours, while ella can be taken up to 120 hours (5 days) after unprotected sex. It is important to note that these are not abortion pills; they work by preventing fertilization or implantation and will not terminate an existing pregnancy.
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